Advances in Non-Small Cell Lung Cancer: Current Insights and Future Directions

Author:

Garg Pankaj1,Singhal Sulabh2,Kulkarni Prakash3,Horne David4,Malhotra Jyoti3,Salgia Ravi3ORCID,Singhal Sharad S.3ORCID

Affiliation:

1. Department of Chemistry, GLA University, Mathura 281406, Uttar Pradesh, India

2. Department of Internal Medicine, Drexel University College of Medicine, Philadelphia, PA 19104, USA

3. Departments of Medical Oncology & Therapeutics Research, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA

4. Departments of Molecular Medicine, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA

Abstract

The leading cause of cancer deaths worldwide is attributed to non-small cell lung cancer (NSCLC), necessitating a continual focus on improving the diagnosis and treatment of this disease. In this review, the latest breakthroughs and emerging trends in managing NSCLC are highlighted. Major advancements in diagnostic methods, including better imaging technologies and the utilization of molecular biomarkers, are discussed. These advancements have greatly enhanced early detection and personalized treatment plans. Significant improvements in patient outcomes have been achieved by new targeted therapies and immunotherapies, providing new hope for individuals with advanced NSCLC. This review discusses the persistent challenges in accessing advanced treatments and their associated costs despite recent progress. Promising research into new therapies, such as CAR-T cell therapy and oncolytic viruses, which could further revolutionize NSCLC treatment, is also highlighted. This review aims to inform and inspire continued efforts to improve outcomes for NSCLC patients globally, by offering a comprehensive overview of the current state of NSCLC treatment and future possibilities.

Funder

The National Cancer Institute of the National Institutes of Health

United States Department of Defense

Publisher

MDPI AG

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