Metabolic and Biochemical Effects of Pyrroloquinoline Quinone (PQQ) on Inflammation and Mitochondrial Dysfunction: Potential Health Benefits in Obesity and Future Perspectives

Author:

Charrier Davide1ORCID,Cerullo Giuseppe1ORCID,Carpenito Roberta2,Vindigni Vincenzo2ORCID,Bassetto Franco2,Simoni Luca1,Moro Tatiana1ORCID,Paoli Antonio13ORCID

Affiliation:

1. Department of Biomedical Sciences, University of Padova, 35122 Padua, Italy

2. Plastic and Reconstructive Surgery Unit, Department of Neurosciences, University of Padua, 35122 Padua, Italy

3. Research Center for High Performance Sport, UCAM Catholic University of Murcia, 30107 Murcia, Spain

Abstract

Obesity is defined as a complex, systemic disease characterized by excessive and dysfunctional adipose tissue, leading to adverse health effects. This condition is marked by low-grade inflammation, oxidative stress, and metabolic abnormalities, including mitochondrial dysfunction. These factors promote energy dysregulation and impact body composition not only by increasing body fat but also by promoting skeletal muscle mass atrophy. The decline in muscle mass is associated with an increased risk of all-cause mortality in individuals with this disease. The European Food Safety Authority approved pyrroloquinoline quinone (PQQ), a natural compound, as a dietary supplement in 2018. This narrative review aims to provide a comprehensive overview of the potential role of PQQ, based on its anti-inflammatory and antioxidant properties, in addressing dysfunctional adipose tissue metabolism and related disorders.

Publisher

MDPI AG

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