Changes in Faecal Microbiota Profile and Plasma Biomarkers following the Administration of an Antioxidant Oleuropein-Rich Leaf Extract in a Rat Model Mimicking Colorectal Cancer-Reference-Cited by-同舟云学术

Changes in Faecal Microbiota Profile and Plasma Biomarkers following the Administration of an Antioxidant Oleuropein-Rich Leaf Extract in a Rat Model Mimicking Colorectal Cancer

Published:2024-06-14 Issue:6 Volume:13 Page:724
ISSN:2076-3921
Container-title:Antioxidants
language:en
Short-container-title:Antioxidants

Author:

Chioccioli Sofia¹^ORCID,Rocchetti Gabriele²^ORCID,Ruzzolini Jessica³,Urciuoli Silvia⁴^ORCID,Vitali Francesco⁵⁶^ORCID,Bartolucci Gianluca¹^ORCID,Pallecchi Marco¹^ORCID,Caderni Giovanna¹,De Filippo Carlotta⁵^ORCID,Nediani Chiara³^ORCID,Lucini Luigi⁷^ORCID

Affiliation:

1. Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, 50134 Florence, Italy

2. Department of Animal Science, Food and Nutrition, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy

3. Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, 50134 Florence, Italy

4. PhytoLab (Pharmaceutical, Cosmetic, Food Supplement Technology and Analysis)-DiSIA, Department of Statistics, Informatics, Applications “Giuseppe Parenti”, Scientific and Technological Pole, University of Florence, 50019 Sesto Fiorentino, Italy

5. Institute of Agricultural Biology and Biotechnology, National Research Council (CNR), Via Moruzzi, 1, 56124 Pisa, Italy

6. Research Centre for Agriculture and Environment, Council for Agricultural Research and Economics (CREA), Via di Lanciola 12/A, 50125 Florence, Italy

7. Department for Sustainable Food Process, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy

Abstract

Oleuropein (OLE), a phenolic compound particularly abundant in the olive leaves, has been reported to have beneficial activities against colorectal cancer (CRC). In vitro studies suggested that these latter could be due to a modulation of the intestinal microbiota. Aiming to evaluate if OLE could affect the intestinal microbiota and the plasma metabolome, an antioxidant oleuropein-rich leaf extract (ORLE) was administered for one week to PIRC rats (F344/NTac-Apcam1137), a genetic model mimicking CRC. ORLE treatment significantly modulated the gut microbiota composition. Plasma metabolomic profiles revealed a significant predictive ability for amino acids, medium-chain fatty acids, and aldehydes. Pathway analysis revealed a significant decrease in phosphatidylcholine accumulation (LogFC = −1.67) in PIRC rats. These results suggest a significant effect of ORLE administration on faecal microbiota profiles and plasma metabolomes, thereby offering new omics-based insights into its protective role in CRC progression.

Funder

National Recovery and Resilience Plan

Italian Ministry of University and Research

European Union—NextGenerationEU

“ON Foods—Research and Innovation Network on Food and Nutrition Sustainability, Safety and Security—Working ON Foods”

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-3921/13/6/724/pdf

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