Affiliation:
1. Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw, Poland
Abstract
Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (ROS) by mitochondria, (2) the presence of a substantial array of redox enzymes such as respiratory chain, and (3) the responsiveness of mitochondria to the cellular redox state. Within the inner mitochondrial membrane, a group of potassium channels, including ATP-regulated, large conductance calcium-activated, and voltage-regulated channels, is present. These channels play a crucial role in conditions such as cytoprotection, ischemia/reperfusion injury, and inflammation. Notably, the activity of mitochondrial potassium channels is intricately governed by redox reactions. Furthermore, the regulatory influence extends to other proteins, such as kinases, which undergo redox modifications. This review aims to offer a comprehensive exploration of the modulation of mitochondrial potassium channels through diverse redox reactions with a specific focus on the involvement of ROS.
Funder
Polish National Science Centre
Reference142 articles.
1. Mitochondria: A Hub of Redox Activities and Cellular Distress Control;Kakkar;Mol. Cell. Biochem.,2007
2. The Mitochondrial Electron Transport and Oxidative Phosphorylation System;Hatefi;Annu. Rev. Biochem.,1985
3. Skulachev, V.P., Vyssokikh, M.Y., Chernyak, B.V., Mulkidjanian, A.Y., Skulachev, M.V., Shilovsky, G.A., Lyamzaev, K.G., Borisov, V.B., Severin, F.F., and Sadovnichii, V.A. (2023). Six Functions of Respiration: Isn’t It Time to Take Control over ROS Production in Mitochondria, and Aging Along with It?. Int. J. Mol. Sci., 24.
4. Oxidative Phosphorylation at the Fin de Siècle;Saraste;Science,1999
5. Mitochondrial Ion Channels/Transporters as Sensors and Regulators of Cellular Redox Signaling;Ryu;Antioxid. Redox Signal.,2014
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献