Role of NADPH Oxidases in Stroke Recovery-Reference-Cited by-同舟云学术

Role of NADPH Oxidases in Stroke Recovery

Published:2024-08-30 Issue:9 Volume:13 Page:1065
ISSN:2076-3921
Container-title:Antioxidants
language:en
Short-container-title:Antioxidants

Author:

Choi Dong-Hee¹²,Choi In-Ae¹³,Lee Jongmin¹⁴^ORCID

Affiliation:

1. Center for Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University, Seoul 05029, Republic of Korea

2. Department of Medical Science, Konkuk University School of Medicine, Konkuk University, Seoul 05029, Republic of Korea

3. Department of Occupational Therapy, Division of Health, Baekseok University, Cheonan-si 31065, Republic of Korea

4. Department of Rehabilitation Medicine, Konkuk University School of Medicine, Konkuk University, Seoul 05029, Republic of Korea

Abstract

Stroke is one of the most significant causes of death and long-term disability globally. Overproduction of reactive oxygen species by NADPH oxidase (NOX) plays an important role in exacerbating oxidative stress and causing neuronal damage after a stroke. There is growing evidence that NOX inhibition prevents ischemic injury and that the role of NOX in brain damage or recovery depends on specific post-stroke phases. In addition to studies on post-stroke neuroprotection by NOX inhibition, recent reports have also demonstrated the role of NOX in stroke recovery, a critical process for brain adaptation and functional reorganization after a stroke. Therefore, in this review, we investigated the role of NOX in stroke recovery with the aim of integrating preclinical findings into potential therapeutic strategies to improve stroke recovery.

Funder

National Research Foundation of Korea (NRF) grant funded by the Korea government

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-3921/13/9/1065/pdf

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