Author:
Lopatka Pavol,Gavenda Michal,Markovič Martin,Koóš Peter,Gracza Tibor
Abstract
This work describes the total synthesis of jaspine B involving the highly diastereoselective Pd(II)-catalysed carbonylative cyclisation in the preparation of crucial intermediates. New conditions for this transformation were developed and involved the pBQ/LiCl as a reoxidation system and Fe(CO)5 as an in situ source of stoichiometric amount of carbon monoxide (1.5 molar equivalent). In addition, we have demonstrated the use of a flow reactor adopting proposed conditions in the large-scale preparation of key lactones.
Funder
Slovak Research and Development Agency
Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
Subject
Physical and Theoretical Chemistry,Catalysis
Cited by
3 articles.
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