Effect of Different Medium-Chain Triglycerides on Glucose Metabolism in High-Fat-Diet Induced Obese Rats
Author:
Xia Jiaheng1, Wang Zhixin1, Yu Ping12, Yan Xianghui3, Zhao Junxin4, Zhang Guohua5, Gong Deming6, Zeng Zheling27ORCID
Affiliation:
1. School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China 2. Jiangxi Province Key Laboratory of Edible and Medicinal Resources Exploitation, Nanchang University, Nanchang 330031, China 3. School of Resources and Environment, Nanchang University, Nanchang 330031, China 4. School of Food Science and Technology, Nanchang University, Nanchang 330031, China 5. Institute of Biological Resources, Jiangxi Academy of Sciences, Nanchang 330096, China 6. New Zealand Institute of Natural Medicine Research, 8 Ha Crescent, Auckland 2104, New Zealand 7. State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang 330047, China
Abstract
Obesity can be associated with significant metabolic disorders. Our previous study found that medium-chain triglycerides (MCTs) improved lipid metabolism in obese rats. However, scant attention has been given to exploring the impact of MCTs on glucose metabolism in obese rats. This study is designed to examine the effects and mechanisms of three distinct MCTs on glucose metabolism in obese rats. To induce obesity, Sprague–Dawley (SD) rats were fed a high-fat diet, followed by a 12-week treatment with caprylic triglyceride (CYT), capric triglyceride (CT), and lauric triglyceride (LT). The results showed that three types of MCT intervention reduced the levels of lipids (TC, TG, LDL-c, and HDL-c), hyperglycemia, insulin resistance (insulin, OGTT, HOMA-IR, and ISI), and inflammatory markers (IL-4, IL-1β, and TNF-α) in obese rats (p < 0.01), The above parameters have been minimally improved in the high-fat restoring group (HR) group. MCTs can modulate the PI3K/AKT signaling pathways to alleviate insulin resistance and improve glucose metabolism in obese rats. Furthermore, MCTs can activate peroxisome proliferator-activated receptor (PPAR) γ and reduce the phosphorylation of PPARγser237 mediated by CDK5, which can improve insulin sensitivity without lipid deposition in obese rats. Among the MCT group, CT administration performed the best in the above pathways, with the lowest blood glucose level and insulin resistance. These findings contribute to a deeper understanding of the connection between health benefits and the specific type of MCT employed.
Funder
National Natural Science Foundation of China Jiangxi Provincial Natural Science Foundation Central Government Guide Local Special Fund Project for Scientific and Technological Development of Jiangxi Province Research Program of State Key Laboratory of Food Science and Resources, Nanchang University Package Pilot Demonstration Program of Jiangxi Academy of Sciences Introduction of Doctoral Program of Jiangxi Academy of Sciences
Subject
Plant Science,Health Professions (miscellaneous),Health (social science),Microbiology,Food Science
Reference50 articles.
1. Coppola, S., Avagliano, C., Calignano, A., and Berni Canani, R. (2021). The protective role of butyrate against obesity and obesity-related diseases. Molecules, 26. 2. Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K.B., Ostolaza, H., and Martin, C. (2020). Pathophysiology of type 2 diabetes mellitus. Int. J. Mol. Sci., 21. 3. Type 2 diabetes;Ahmad;Lancet,2022 4. Vazquez-Carrera, M., and Wahli, W. (2022). PPARs as key mediators in the regulation of metabolism and inflammation. Int. J. Mol. Sci., 23. 5. Hu, N., Chen, C., Wang, J., Huang, J., Yao, D., and Li, C. (2021). Atorvastatin ester regulates lipid metabolism in hyperlipidemia rats via the PPAR-signaling pathway and HMGCR expression in the liver. Int. J. Mol. Sci., 22.
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