Exploring the Impact of Infusion Parameters and In Vitro Digestion on the Phenolic Profile and Antioxidant Capacity of Guayusa (Ilex guayusa Loes.) Tea Using Liquid Chromatography, Diode Array Detection, and Electrospray Ionization Tandem Mass Spectrometry

Author:

Kelebek Hasim1ORCID,Sasmaz Hatice Kubra1ORCID,Aksay Ozge1ORCID,Selli Serkan2ORCID,Kahraman Ozan3,Fields Christine3

Affiliation:

1. Department of Food Engineering, Faculty of Engineering, Adana Alparslan Turkes Science and Technology University, 01250 Adana, Turkey

2. Department of Food Engineering, Faculty of Engineering, University of Cukurova, 01330 Adana, Turkey

3. Applied Food Sciences Inc., 675-B Town Creek Road, Kerrville, TX 78028, USA

Abstract

Guayusa tea is derived from the leaves of the Ilex guayusa Loes. plant, which is native to the Amazon rainforest. Beyond its pleasant sensory properties, Guayusa tea is rich in antioxidants, phenolics, and minerals. In this study, the effects of infusion time, temperature, and solvent conditions on the color, antioxidant capacity, total phenolic content, phenolic profile, and antimicrobial activity of Guayusa (Ilex guayusa Loes.) tea were investigated. Guayusa tea samples were prepared using two different solvents, ethanol and water, with 4, 6, and 8-h infusions at 60 and 70 °C. Liquid chromatography, diode array detection, and electrospray ionization tandem mass spectrometry (LC-DAD-ESI-MS/MS) were used to determine a comprehensive profile of phenolic compounds and to detect differences due to infusion conditions. Moreover, after the Guayusa tea infusion with the highest bioactive properties was determined, the effects of in vitro gastrointestinal digestion on the total phenolic content, antioxidant capacity, and phenolic compounds of the Guayusa tea infusion were measured. Phenolic profile analysis identified 29 compounds, among which chlorogenic acid and its derivatives were predominant. The increase in infusion time was correlated with an elevation in total phenolic content. Significant differences were observed between water and ethanol infusions of Guayusa in terms of phenolics and antioxidants. The total amount of phenolic compounds in the samples prepared with both solvents was found to increase after oral intake, depending on the digestion stage; meanwhile, the amounts of flavonoid compounds and di-O-caffeoylquinic acid derivatives decreased during digestion.

Publisher

MDPI AG

Reference44 articles.

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3. Gan, R.Y., Zhang, D., Wang, M., and Corke, H. (2018). Health Benefits of Bioactive Compounds from the Genus Ilex, a Source of Traditional Caffeinated Beverages. Nutrients, 10.

4. (2023, August 22). Infinium Global Research. Available online: https://www.infiniumglobalresearch.com/reports/global-herbal-tea-market.

5. GRAS (2023, August 22). Notification for Ilex guayusa Leaf Extract (869), Ilex guayusa Leaf Hydroethanolic Extract (870, 883), Available online: https://www.fda.gov/food/gras-notice-inventory/recently-published-gras-notices-and-fda-letters.

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