Broccoli Improves Lipid Metabolism and Intestinal Flora in Mice with Type 2 Diabetes Induced by HFD and STZ Diet

Author:

Li Xin12,Cai Zifan1,Yang Feiyu3,Wang Yunfan1,Pang Xinyi1,Sun Jing1,Li Xiangfei1,Lu Yingjian1

Affiliation:

1. College of Food Science and Engineering, Nanjing University of Finance and Economics, Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China

2. Priority Academic Program, Development of Jiangsu Higher Education Institutions (PAPD), Nanjing 210023, China

3. College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China

Abstract

Globally, type 2 diabetes (T2DM) is on the rise. Maintaining a healthy diet is crucial for both treating and preventing T2DM.As a common vegetable in daily diet, broccoli has antioxidant, anti-inflammatory and anticarcoma physiological activities. We developed a mouse model of type 2 diabetes and carried out a systematic investigation to clarify the function of broccoli in reducing T2DM symptoms and controlling intestinal flora. The findings demonstrated that broccoli could successfully lower fasting blood glucose (FBG), lessen insulin resistance, regulate lipid metabolism, lower the levels of TC, TG, LDL-C, and MDA, stop the expression of IL-1β and IL-6, and decrease the harm that diabetes causes to the pancreas, liver, fat, and other organs and tissues. Furthermore, broccoli altered the intestinal flora’s makeup in mice with T2DM. At the genus level, the relative abundance of Allobaculum decreased, and that of Odoribacter and Oscillospira increased; At the family level, the relative abundances of Odoribacteraceae, Rikenellaceae and S24-7 decreased, while the relative abundances of Erysipelotrichaceae and Rikenellaceae increased.

Funder

National Natural Science Foundation of China

Natural Science Foundation of the Higher Education Institutions of Jiangsu Province, China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

MDPI AG

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