Stability and Sensitivity Analysis of the COVID-19 Spread with Comorbid Diseases

Abstract

This research investigates a model of the spread of COVID-19 in Indonesia by paying attention to comorbid disease, self-quarantine, government-provided quarantine, and vaccination factors. The symmetrical aspects of the model are studied. The evaluation of the model reveals non-endemic and endemic equilibrium points and the basic reproduction number (BRN). We provide the local and global stability analysis of the equilibriums. According to the sensitivity analysis of the BRN, the key parameters impacting the spread of COVID-19 are the susceptible recruitment rate, contact rate, infection death rate, and probability of infected individuals having no comorbidities. In addition, we provide a sensitivity analysis to examine the effect of parameter changes in each subpopulation. We discovered that the natural death rate is the most sensitive parameter based on the sensitivity index after reaching equilibrium. Symmetry aspects appear in some of the visualizations of the model’s solution and the sensitivity of the BRN and parameters.