An All-Dielectric Metamaterial Terahertz Biosensor for Cytokine Detection

Author:

Men Kuo1234,Lian Ziwei1234,Tu Hailing1,Zhao Hongbin1,Wei Qianhui123,Jin Qingxi124,Mao Changhui1,Wei Feng13

Affiliation:

1. State Key Laboratory of Advanced Materials for Smart Sensing, GRINM Group Co., Ltd., Beijing 100088, China

2. GRIMAT Engineering Institute Co., Ltd., Beijing 101402, China

3. GRINM (Guangdong) Institute for Advanced Materials and Technology, Foshan 528051, China

4. General Research Institute for Nonferrous Metals, Beijing 100088, China

Abstract

In this paper, we report an all-dielectric metamaterial terahertz biosensor, which exhibits a high Q factor of 35 at an 0.82 resonance peak. A structure with an electromagnetically induced transparency effect was designed and fabricated to perform a Mie resonance for the terahertz response. The biosensor exhibits a limit of detection of 100 pg/mL for cytokine interleukin 2 (IL-2) and a linear response for the logarithm of the concentration of IL-2 in the range of 100 pg/mL to 1 μg/mL. This study implicates an important potential for the detection of cytokines in serum and has potential application in the clinical detection of cytokine release syndrome.

Funder

Key-Area Research and Development Program of Guangdong Province

National Natural Science Foundation of China

Publisher

MDPI AG

Subject

Electrical and Electronic Engineering,Mechanical Engineering,Control and Systems Engineering

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