Evaluation of Single-Photon Emission Computed Tomography Myocardial Perfusion Detection Capability through Physical Descriptors

Abstract

A comprehensive validation of data acquired by different myocardial perfusion imaging (MPI) systems was performed to evaluate contrast, self-attenuation properties, and perfusion detection capability. An anthropomorphic phantom with a myocardial insert and perfusion defect was used to simulate 99mTc-tetrofosmin distribution. Different MPI systems were evaluated: a SPECT system with iterative reconstruction algorithms and resolution recovery (IRR) with/without scatter correction (SPECT-IRR-SC and SPECT-IRR), and a cardio-centric IQ SPECT/CT system with IRR, with/without scatter and attenuation corrections (IQ-IRR-SC-AC and IQ-IRR). The image quality was assessed through physical descriptors: the contrast between the left ventricular (LV) wall and LV inner chamber (CLV/LVIC), intrinsic contrast (IC), and net contrast (NC). CLV/LVIC was found to be superior for IQ-IRR-SC-AC. The IC results showed non-uniformity of the signal intensity in the LV wall for the SPECT systems. The lowest IC values were obtained for IQ-IRR-SC-AC, except for septal position, where an underestimation of the signal intensity was revealed. The NC was found to be the highest for IQ-IRR-SC-AC and SPECT-IRR-SC. Additionally, for IQ-IRR-SC-AC, the NC increased in posterior and septal positions compared to IQ-IRR, enabling better perfusion detection capability over short-axis images. IQ-IRR showed performances comparable to SPECT-IRR. The characterization and evaluation perfusion detection capability of the MPI systems enabled the investigation of the systems’ performance and limitations.