Author:
Bazargan M,Faghihi M,Chitsaz M
Abstract
There is a growing interest for the beneficial effect of magnesium
(Mg) in cardiovascular disorders. A number of cardiovascular
disorders including myocardial infarction, arrhythmias and
congestive heart failure have been associated with low extracellular or intracellular concentrations of Mg. The efficiency of the
preconditioning effect of Mg on cardiac function and infarct size
in the globally ischemic-reperfused isolated rat heart was studied
together with the role of ATP-sensitive potassium (KATP) channels
in protection induced by Mg. Rat hearts were Langendorff
perfused, subjected to 30 min of global ischemia and 90 min of
reperfusion, including treatment groups which focused on
different times of Mg (8 mmol/l) use. Infarct size was measured
by triphenyltetrazolium chloride (TTC) method. The left
ventricular function was assessed by left ventricular developed
pressure (LVDP), heart rate (HR) and coronary flow (CF). The
administration of Mg before ischemia had an anti-infarct effect in
rat hearts and improved cardiac function. The protective effects
of magnesium was abolished by the blocking of KATP channels and
suggests that K-ATP channel has an important role in the heart
protection effect of Mg as a preconditioning agent.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
11 articles.
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