Age-Dependent Changes in the Function of Mitochondrial Membrane Permeability Transition Pore in Rat Liver Mitochondria
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Published:2021-10-30
Issue:
Volume:
Page:905-911
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ISSN:1802-9973
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Container-title:Physiological Research
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language:en
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Short-container-title:Physiol Res
Author:
Endlicher R,Drahota Z,Kučera O,Červinková Z
Abstract
Mitochondria play an important role in the cell aging process.
Changes in calcium homeostasis and/or increased reactive
oxygen species (ROS) production lead to the opening of
mitochondrial permeability transition pore (MPTP), depolarization
of the inner mitochondrial membrane, and decrease of ATP
production. Our work aimed to monitor age-related changes in
the Ca2+ ion effect on MPTP and the ability of isolated rat liver
mitochondria to accumulate calcium. The mitochondrial calcium
retention capacity (CRC) was found to be significantly affected by
the age of rats. Measurement of CRC values of the rat liver
mitochondria showed two periods when 3 to 17-week old rats
were tested. 3-week and 17-week old rats showed lower CRC
values than 7-week old animals. Similar changes were observed
while testing calcium-induced swelling of rat liver mitochondria.
These findings indicate that the mitochondrial energy production
system is more resistant to calcium-induced MPTP opening
accompanied by the damaging effect of ROS in adult rats than in
young and aged animals.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
1 articles.
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