Introduction to DOK2 and its Potential Role in Cancer-Reference-Cited by-同舟云学术

Introduction to DOK2 and its Potential Role in Cancer

Published:2021-10-31 Issue: Volume: Page:671-685
ISSN:1802-9973
Container-title:Physiological Research
language:en
Short-container-title:Physiol Res

Author:

SUN P¹,LI R¹,MENG Y¹,XI S¹,WANG Q¹,YANG X²,PENG X¹,CAI J³

Affiliation:

1. Laboratory of Oncology, Center for Molecular Medicine, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, China

2. Department of Pharmacology, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, China

3. Department of Oncology, First Affiliated Hospital of Yangtze University, Jingzhou, China

Abstract

Cancer is a complex, multifactorial disease that modern medicine ultimately aims to overcome. Downstream of tyrosine kinase 2 (DOK2) is a well-known tumor suppressor gene, and a member of the downstream protein DOK family of tyrosine kinases. Through a search of original literature indexed in PubMed and other databases, the present review aims to extricate the mechanisms by which DOK2 acts on cancer, thereby identifying more reliable and effective therapeutic targets to promote enhanced methods of cancer prevention and treatment. The review focuses on the role of DOK2 in multiple tumor types in the lungs, intestines, liver, and breast. Additionally, we discuss the potential mechanisms of action of DOK2 and the downstream consequences via the Ras/MPAK/ERK or PI3K/AKT/mTOR signaling pathways.

Publisher

Institute of Physiology of the Czech Academy of Sciences

Subject

General Medicine,Physiology

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