Abstract
Gastrointestinal hormones play an important role in the
neuroendocrine regulation of food intake and postprandial
satiety. Ghrelin is a 28-amino acid orexigenic peptide produced
mainly by the stomach that is involved in both the long-term
regulation of body weight and the short-term regulation of
postprandial satiety. Impairments in ghrelin secretion may in
concert with other factors play an important role in the
development of both obesity and anorexia nervosa. Despite an
intensive research the critical factors regulating physiological
postprandial ghrelin response in healthy individuals and its
modification by the presence of obesity and anorexia nervosa are
only partially understood. The potential contribution of ghrelin to
the differences of diet- vs. surgical-induced weight losses in
morbidly obese patients is now also being recognized. The aim of
this review is to summarize the current knowledge about the
physiology and pathophysiology of ghrelin and to discuss its
potential in the prevention and/or treatment of obesity and
anorexia nervosa.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
21 articles.
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