Author:
Lohajová Behulová R,Bugalová A,Bugala J,Struhárňanská E,Šafranek M,Juráš I
Abstract
Cancer belongs to multifactorial diseases characterized by uncontrolled growth and proliferation of abnormal cells. Breast cancer, non-small cell lung cancer, and colorectal cancer are the most frequently diagnosed malignancies with a high mortality rate. These carcinomas typically contain multiple genetically distinct subpopulations of tumor cells leading to tumor heterogeneity, which promotes the aggressiveness of the disease. Early diagnosis is necessary to increase patient progression-free survival. Particularly, miRNAs present in exosomes derived from tumors represent potential biomarkers suitable for early cancer diagnosis. Identification of miRNAs by liquid biopsy enables a personalized approach with the subsequent better clinical management of patients. This review article highlights the potential of circulating exosomal miRNAs in early breast, non-small cell lung, and colorectal cancer diagnosis.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Reference113 articles.
1. Cancer Burden Statistics and Trends Across Europe. 2020. p. ECIS. https://ecis.jrc.ec.europa.eu/
2. Cao J, Yan Q. Cancer epigenetics, tumor immunity, and immunotherapy. Trends in Cancer 2020;6:580-592. https://doi.org/10.1016/j.trecan.2020.02.003
3. Takeshima H, Ushijima T. Accumulation of genetic and epigenetic alterations in normal cells and cancer risk. Precis Oncol 2019;3:1-8. https://doi.org/10.1038/s41698-019-0079-0
4. Eu Commision. Council conclusions on personalised medicine for patients. Off J Eur Union 2015;58:1-32.
5. Gambardella V, Tarazona N, Cejalvo JM, Lombardi P, Huerta M, Roselló S, Fleitas T, Roda D, Cervantes A. Personalized medicine: recent progress in cancer therapy. cancers (Basel) 2020;12:1009. https://doi.org/10.3390/cancers12041009