T45G and G276T Adiponectin Gene Polymorphisms in Primary Aldosteronism and Healthy Controls in an East Slovak Population

Abstract

Metabolic complications are frequent in primary aldosteronism (PA) and adiponectin gene polymorphisms seem to confer a genetic risk for metabolic alterations. Aim of the study was to evaluate the prevalence of metabolic symptoms in patients with PA compared to controls and the prevalence of two single nucleotide polymorphisms (SNPs), T45G and G276T, in the adiponectin gene and their relationship to metabolic syndrome (MS). The study involved 47 patients with PA and 90 controls selected from general population. Body mass index (BMI), and selected biochemical parametres were examined, and the mentioned SNPs were genotyped in all subjects. PA patients had a significantly higher BMI (p0.0001), blood glucose level (p0.01), and triglycerides (p0.0005) compared to controls. There were no significant differences in the prevalence of the studied genotypes of adiponectin gene polymorphisms. The 276GT genotype was linked with lower levels of triglycerides (p≤0.05), while 276GG was related to higher levels of triglycerides (p=0.01). A similar but non-significant tendency was observed in relation to cholesterol levels. We can conclude that PA patients with the 276GT genotype have lower triglycerides levels, but there are not significant differences in the distribution of genotypes and alleles among PA patients and controls in an East Slovak population.