Author:
Perovic A,Vuckovic T,Cvijic G,Djordjevic J,Davidovic V
Abstract
The effect of exogenous noradrenaline (NA) (1.6 mg.kg-1 i.p.,
35 min prior sacrifice) on the activity of antioxidant enzymes
(AOE) copper zinc superoxide dismutase (CuZnSOD), manganese
superoxide dismutase (MnSOD) and catalase (CAT), as well as
lipid peroxides (LP) concentration were studied in the rat
interscapular brown adipose tissue (IBAT) and heart of saline
(controls) and Nω-nitro-L-arginine methyl ester (L-NAME) treated
rats (10 mg.kg-1, i.p., during 3 days and 20 min before NA). NA
differently affects both AOE activities and LP production in the
IBAT and heart. Thus, NA inhibited the activity of all IBAT AOE
and LP production while in the heart it markedly increased CAT
activity only, but had no effect on any of SODs activities and LP
concentration. L-NAME, a nitric oxide synthase blocker,
completely abolished the NA-induced inhibition of the IBAT AOE
and LP production, whereas in the heart it was without effect. In
conclusion, these results indicate that both NA and L-NAME
effects on AOE activity and LP production are tissue specific and
also suggest that nitric oxide mediates the NA-induced inhibition
of AOE activity and LP production in the IBAT only.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
1 articles.
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