A Study on Molecular Mechanisms of Adiposis Induced by Long-Term Treatment of High-Fat and High-Sucrose in C57BL/6J Mice-Reference-Cited by-同舟云学术

A Study on Molecular Mechanisms of Adiposis Induced by Long-Term Treatment of High-Fat and High-Sucrose in C57BL/6J Mice

Published:2019-02-28 Issue: Volume: Page:75-87
ISSN:1802-9973
Container-title:Physiological Research
language:en
Short-container-title:Physiol Res

Author:

Li Xiaodan¹,Tu Peipei²,Umar Muhammad¹,Liu Qiqi¹,Luo Wenya¹,Yang Xingkai¹,Zhu Jianghong²,Kong Deling¹,Li Minggang¹

Affiliation:

1. State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, Tianjin, China

2. College of Life Science, Anhui Medical University, Hefei, China

Abstract

Adiposis is reputed as a twin disease of type 2 diabetes and greatly harmful to human health. In order to understand the molecular mechanisms of adiposis, the changes of physiological, pathological, epigenetic and correlative gene expression were investigated during the adiposis development of C57BL/6J mice induced by long time (9 months) high-fat and high-sucrose diet (HFSD) sustainably. The results showed that mRNA transcription level of the Leptin, Glut4 and Glut2 genes have been obviously changed, which exhibit a negative correlation with methylation on their promoter DNA. The results also revealed that HFSD induced higher level of DNA methyltransferase 1 (DNMT1) in fat tissue might play important role in regulating the changes of methylation pattern on Glut4 and Leptin genes, and which might be one of the molecular mechanisms for the adiposis development.

Publisher

Institute of Physiology of the Czech Academy of Sciences

Subject

General Medicine,Physiology

Reference37 articles.

1. BARRÈS R, OSLER ME, YAN J, RUNE A, FRITZ T, CAIDAHL K, KROOK A, ZIERATH JR: Non-CpG methylation of the PGC-1α promoter through DNMT3B controls mitochondrial density. Cell Metab 10: 189-198, 2009.

2. BASTARD JP, MAACHI M, LAGATHU C, KIM MJ, CARON M, VIDAL H, CAPEAU J, FEVE B: Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17: 4-12, 2006.

3. BERNARDIS LL, PATTERSON BD: Correlation between 'lee index' and carcass fat content in weanling and adult female rats with hypothalamic lesions. J Endocrinol 40: 527-528, 1968.

4. BRUNT EM, JANNEY CG, DI BISCEGLIE AM, NEUSCHWANDER-TETRI BA, BACON BR: Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 94: 2467-2474, 1999.

5. BUSCHEMEYER WC 3RD, FREEDLAND SJ: Obesity and prostate cancer: epidemiology and clinical implications. Eur Urol 52: 331-343, 2007.

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Study on the Pharmacological Character of an Insulin-Mimetic Small Molecular Compound of Vanadyl Trehalose;Physiological Research;2020-06-30

2. Epigenetics: At the Crossroads Between Genetic and Environmental Determinants of Disease;Bone Health;2019