Renal Sympathetic Denervation in Resistant Arterial Hypertension: Long Term and Updated Results

Author:

Peregrin J.H.1,Novotný J.1,Rohál T.2,Šochman J.3

Affiliation:

1. Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

2. Clinic of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

3. Clinic of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Abstract

The present paper is an extension to our earlier publication (Šochman et al. 2016) documenting a beneficial effect of renal sympathetic denervation on pharmacologically uncontrollable hypertension in a group of seven patients followed up for 1-2 years post-procedure. The same patients remained on ambulatory follow-up for another 5-6 years, with the beneficial effect persisting throughout the follow-up period while on the same medication.

Publisher

Institute of Physiology of the Czech Academy of Sciences

Subject

General Medicine,Physiology

Reference13 articles.

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2. BHATT DL, KANDZARI DE, O´NEILL WW, D’AGOSTINO R, FLACK JM, KATZEN BT, LEON MB, LIU M, MAURI L, NEGOITA M, COHEN SA, OPARIL S, ROCHA-SINGH K, TOWNSEND RR, BAKRIS G: A controlled trial of renal denervation for resistant hypertension. N Engl J Med 370: 1393-1401, 2014.

3. CONSIGNY PM, DAVALIAN D, DONN R, HU J, RIESER M, STOLARIK D: Chemical renal denervation in rat. Cardiovasc Intervent Radiol 37: 218-223, 2014.

4. ESLER MD, KRUM H, SOBOTKA PA, SCHLAICH MP, SCHMIEDER RE, BÖHM M: Renal sympathetic denervation in patients with treatment-resistant hypertension (the SYMPLICITY HTN-2 Trial): a randomised controlled trial. Lancet 376: 1903-1909, 2010.

5. FADL ELMULA FE, JIN Y, YANG WY, THIJS L, LU YC, LARSTOP AC, PERSU A, SAPOVAL M, ROSA J, WIDIMSKÝ P, JACOBS L, RENKIN J, PETRÁK O, CHATTELIER G, SHIMADA K, WIDIMSKÝ J, KARIO K, AZIZI M, KJELDSEN SE, STAESSEN JA: European Network Coordinating Research On Renal Denervation (ENCOReD) Consortium. Meta-analysis of randomized controlled trials of renal denervation in treatment-resistant hypertension. Blood Press 24: 263-274, 2015.

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