Author:
Prázný M,Ježková J,Horová E,Lazárová V,Hána V,Kvasnička J,Pecen L,Marek J,Škrha J,Kršek M
Abstract
The aim of the study was to evaluate skin microvascular
reactivity (MVR) and possible influencing factors (fibrinolysis,
oxidative stress, and endothelial function) in patients with
Cushing’s syndrome. Twenty-nine patients with active Cushing’s
syndrome (ten of them also examined after a successful
operation) and 16 control subjects were studied. Skin MVR was
measured by laser Doppler flowmetry during post-occlusive
(PORH) and thermal hyperemia (TH). Malondialdehyde and
Cu,Zn-superoxide dismutase were used as markers of oxidative
stress. Fibrinolysis was estimated by tissue plasminogen activator
(tPA) and its inhibitor (PAI-1). N-acetyl-β-glucosaminidase,
E-selectin, P-selectin, and ICAM-1 were used as markers of
endothelial function. Oxidative stress and endothelial dysfunction
was present in patients with hypercortisolism, however,
increased concentration of ICAM-1 was also found in patients
after the operation as compared to controls (290.8±74.2 vs.
210.9±56.3 ng.ml-1, p<0.05). Maximal perfusion was significantly
lower in patients with arterial hypertension during PORH and TH
(36.3±13.0 vs. 63.3±32.4 PU, p<0.01, and 90.4±36.6 vs.
159.2±95.3 PU, p<0.05, respectively) and similarly the velocity
of perfusion increase during PORH and TH was lower (3.2±1.5
vs. 5.2±3.4 PU.s-1, p<0.05, and 0.95±0.6 vs. 1.8±1.1 PU.s-1,
p<0.05, respectively). The most pronounced impairment of
microvascular reactivity was present in patients with combination
of arterial hypertension and diabetes mellitus.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
26 articles.
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