Author:
Wilund KR,Feeney LA,Tomayko EJ,Weiss EP,Hagberg JM
Abstract
Abnormal cholesterol metabolism, including low intestinal
cholesterol absorption and elevated synthesis, is prevalent in
diabetes, obesity, hyperlipidemia, and the metabolic syndrome.
Diet-induced weight loss improves cholesterol absorption in these
populations, but it is not known if endurance exercise training
also improves cholesterol homeostasis. To examine this, we
measured circulating levels of campesterol, sitosterol, and
lathosterol in 65 sedentary subjects (average age 59 years; with
at least one metabolic syndrome risk factor) before and after
6 months of endurance exercise training. Campesterol and
sitosterol are plant sterols that correlate with intestinal
cholesterol absorption, while lathosterol is a marker of whole
body cholesterol synthesis. Following the intervention, plant
sterol levels were increased by 10 % (p<0.05), but there was no
change in plasma lathosterol. In addition, total and LDLcholesterol were reduced by 0.16 mmol and 0.10 mmol,
respectively (p<0.05), while HDL-C levels increased by
0.09 mmol (p<0.05). Furthermore, the change in plant sterols
was positively correlated with the change in VO2max (r = 0.310,
p=0.004), independent of other metabolic syndrome risk factors.
These data indicate that exercise training reduces plasma
cholesterol despite increasing cholesterol absorption in subjects
with metabolic syndrome risk factors.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
24 articles.
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