Author:
Vyskočil F,Malomouzh AI,Nikolsky EE
Abstract
There are two principal mechanisms of acetylcholine (ACh)
release from the resting motor nerve terminal: quantal and nonquantal (NQR); the former being only a small fraction of the total, at least at rest. In the present article we summarize basic research about the NQR that is undoubtedly an important trophic
factor during endplate development and in adult neuromuscular
contacts. NQR helps to eliminate the polyneural innervation of
developing muscle fibers, ensures higher excitability of the adult
subsynaptic membrane by surplus polarization and protects the
RMP from depolarization by regulating the NO cascade and
chloride transport. It shortens the endplate potentials by
promoting postsynaptic receptor desensitization when AChE is
inhibited during anti-AChE poisoning. In adult synapses, it can
also activate the electrogenic Na+/K+-pump, change the degree
of synchronization of quanta released by the nerve stimulation
and affects the contractility of skeletal muscles.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
51 articles.
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