Author:
Tyapkina O,Volkov E,Nurullin L,Shenkman B,Kozlovskaya I,Nikolsky E,Vyskočil F
Abstract
Antiorthostatic hindlimb suspension (unloading) decreased the
resting membrane potential (RMP) of skeletal muscle fibers in
fast extensor digitorum longus (EDL) and slow soleus (SOL)
muscle of the rat by about 10 % within 7 days and more.
Inactivation of the membrane Na+, K+-pump by ouabain brought
about similar depolarization as unloading. The increased sodium
permeability of the membrane was excluded as the major cause
of this depolarization by experiments in which TRIS was
substituted for Na+ in the medium. On the other hand, the
decrease in the electrogenic participation of the Na+,K+-pump is
apparently one of the causes of RMP decrease during
hypogravity, in EDL muscle in particular.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
14 articles.
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