Pancreatic stellate cells - rising stars in pancreatic pathologies-Reference-Cited by-同舟云学术

Pancreatic stellate cells - rising stars in pancreatic pathologies

Published:2021-12-30 Issue:S4 Volume: Page:S597-S616
ISSN:1802-9973
Container-title:Physiological Research
language:en
Short-container-title:Physiol Res

Author:

Hrabák P,Kalousová M¹,Krechler T,Zima T

Affiliation:

1. 2Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic. marta.kalousova@lf1.cuni.cz

Abstract

Pluripotent pancreatic stellate cells (PSCs) receive growing interest in past decades. Two types of PSCs are recognized –vitamin A accumulating quiescent PSCs and activated PSCs- the main producents of extracellular matrix in pancreatic tissue. PSCs plays important role in pathogenesis of pancreatic fibrosis in pancreatic cancer and chronic pancreatitis. PSCs are intensively studied as potential therapeutical target because of their important role in developing desmoplastic stroma in pancreatic cancer. There also exists evidence that PSC are involved in other pathologies like type-2 diabetes mellitus. This article brings brief characteristics of PSCs and recent advances in research of these cells.

Publisher

Institute of Physiology of the Czech Academy of Sciences

Subject

General Medicine,Physiology

Reference140 articles.

1. AOKI H, OHNISHI H, HAMA K, SHINOZAKI S, KITA H, YAMAMOTO H, OSAWA H, SATO K, TAMADA K, SUGANO K: Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated rat pancreatic stellate cells. J Cell Biochem 99: 221-228, 2006. https://doi.org/10.1002/jcb.20906

2. APTE MV, HABER PS, APPLEGATE TL, NORTON ID, MCCAUGHAN GW, KORSTEN MA, PIROLA RC, WILSON JS: Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 43: 128-133, 1998. https://doi.org/10.1136/gut.43.1.128

3. APTE MV, PHILLIPS PA, FAHMY RG, DARBY SJ, RODGERS SC, MCCAUGHAN GW, KORSTEN MA, PIROLA RC, NAIDOO D, WILSON JS: Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology 118: 780–794, 2000. https://doi.org/10.1016/s0016-5085(00)70148-x

4. APTE MV, WILSON JS: Stellate cell activation in alcoholic pancreatitis. Pancreas 27: 316-320, 2003. https://doi.org/10.1097/00006676-200311000-00008

5. ASAHINA K, TSAI SY, LI P, ISHII M, MAXSON RE JR, SUCOV HM, TSUKAMOTO H: Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology 49: 998-1011, 2009. https://doi.org/10.1002/hep.22721