Author:
Zainab Saad Kaddoori ,Masar Basim Mohsin Mohamed ,Nawfal Am. Numan
Abstract
In this work we investigate span 40, span 60 and SA as a gelators and olive oil (OO) as apolar liquid phase to discover the ability of organogel formed to be floating in acidic media and gain a unique gastroretentive dosage form. In addition, take advantage of the chemical
and physical properties of cinnarizine (CN) as a model drug suitable for gastroretentive systems. The floating parameters were studied where the floating lag time and floating duration for organogel in both solid and liquid states. Organogels charecterization were accomplished through the folowing investigatational techniques and analytical methods: table top rheology, optical microscope, Fourier-transform infrared spectroscopy (FTIR) and in- vitro release study. The results showed that all organogels immediately floated and they were floating in both states. Moreover, table top rheology showed that the transition temperature was reversible and higher than 37 ºC except for 7% w/w and 10% w/w SA in OO organogels where, optical images of organogel showed fibrillar network. The FTIR showed peaks associated to carbonyl groups indicated to form gelator-gelator interactions. Moreover, in vitro release study of organogel system showed continuous release CN for 9-12 hours.
Publisher
Al Mustansiriyah University - College of Pharmacy
Reference33 articles.
1. - Lee, Y., et al., Orally disintegrating films focusing on formulation, manufacturing process, and characterization. Journal of Pharmaceutical Investigation, 2017. 47(3): p. 183-201.
2. - Mahboob, M.B.H., et al., Oral films: A comprehensive review. International Current Pharmaceutical Journal, 2016. 5(12): p. 111-117.
3. - Jassal, M., U. Nautiyal, and J. Kundlas, A review: Gastroretentive drug delivery system (grdds). Indian journal of pharmaceutical and biological research, 2015. 3(01): p. 82-92.
4. - Mohamed, M.B.M., et al., Oily in situ gels as an alternative floating platform for ketoconazole release. International Journal of Research in Pharmaceutical Sciences, 2020. 11(2): p. 2638-2649.
5. - Pahwa, R., et al., Role of natural polymers in the development of floating drug delivery systems. Journal of Pharmacy Research, 2010. 3(6): p. 1312-1318.