Affiliation:
1. ÇANAKKALE ONSEKİZ MART ÜNİVERSİTESİ
Abstract
The reaction medium plays a key role in organic synthesis and pharmaceutical research. There are many opinions on choosing the best condition, including cost and environmental implications, but the main requirement is that they have the necessary interaction with solvents to cause dissolution, precipitation, stabilization, or instability. For this purpose, in this article synthesis of the thiazole ring was made under various reaction conditions. So new compounds 2-(isoquinolin-5-ylimino)-3-phenylthiazolidin-4-one (1), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (2), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (3) were synthesized from the reaction between thiourea derivative and monochloroacetic acid, diethyloxalate and chloro acetonitrile. For this synthesizes were created in various reaction conditions, using different bases (sodium acetate/sodyum etoksit/ triethylamine or pyridine) and solvents (1,4-dioxane, toluene, acetic acid, ethanol, tetrahydrofuran, dimethyl formamide). At the end of these reactions, the best efficiency was obtained with the one-pot reaction using THF/DMF, Et3N. The structures of all novel compounds reported herein were established using FT-IR, 1H NMR, and 13C NMR spectra as well as elemental analysis technique.
Publisher
Sakarya University Journal of Science
Reference43 articles.
1. [1] T. Akiyama et al. “Scandium trifluoro- methanesulfonate-catalyzed chemoselective allylation reactions of carbonyl compounds with tetraallylgermane in aqueous media,” Tetrahedron, vol. 55, no. 24, pp. 7499-7508, 1999.
2. [2] M. S. Saini et al. “A review: biological significances of heterocyclic compounds,” International Journal of Pharma Sciences and Research, vol. 4, no. 3, pp. 66-77, 2013.
3. [3] Y. Cheng et al. “Heterocyclic enamines: The versatile intermediates in the synthesis of heterocyclic compounds and natural products,” Current Organic Chemistry, vol. 8, no. 4, pp. 325-51, 2004.
4. [4] N. Kaur “Review on the synthesis of six-membered N, N-heterocycles by microwave irradiation,” Synthetic Communications, vol. 45, no. 10, pp. 1145-82, 2015.
5. [5] N. Kaur “Photochemical reactions: synthesis of six-membered N-heterocycles,” Current Organic Synthesis, vol. 14, no. 7, pp. 972-98, 2017.