Production and Characterization of Colon Targeted pH Sensitive Macrospheres and Investıgation of Release Kinetics
Author:
EREN BELGİN Ezgi1ORCID, DELİBALTA Cankız Gizem2ORCID, ÇİÇEK Hüseyin2ORCID
Affiliation:
1. MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ, FEN FAKÜLTESİ 2. MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ
Abstract
The gastrointestinal track has different pH values at different sections. Thus, it is not easy to carry a drug to the colon for absorption. pH sensitive polymeric macrosphere drug carriers have important advantages such as being able to be taken orally, targeting the active ingredient to the desired area and dosing the active ingredient at the desired concentration for a long time in the target area. In this contex pH sensitive sodium alginate-gelatin macrospheres were produced by the dispersion phase gelling and cross-linking (complex coacervation) process method then loaded with Sternbergia lutea extract in this study. The macrosphere extract release kinetics were investigated for different pH medias that simulates different sections of the gastrointestinal track. As a result, the produced drug carrier macrospheres released the active ingredient at the colon pH (pH 7.0) while at lower pH values did not show a significant extract release. Therefore, it was reported that the produced macrospheres have potential to be used for colon diseases treatments.
Publisher
Sakarya University Journal of Science
Reference27 articles.
1. [1] S. Amidon, J. E. Brown, Dave V. S., “Colon-targeted oral drug delivery systems: design trends and approaches,”An Official Journal of the American Association of Pharmaceutical Scientists, vol. 16, 4, pp: 731-41, 2015. 2. [2] G. V. D. Mooter, Kinget R., “Oral colon-specific drug delivery: a review”,Drug Delivery,vol. 2, no.2, pp.81-93, 1995. 3. [3] Z. Vinarov, M., Abdallah, J. A., Agundez, K., Allegaert, A. W., Basit, M., Braeckmans, J., Ceulemans, M., Corsetti, B. T., Griffin, M., Grimm, D., Keszthelyi, M., Koziolek, C. M., Madla, C., Matthys, L. E., McCoubrey, A., Mitra C., Reppas J., Stappaerts, N., Steenackers, N. L., Trevaskis P., Augustijns, “Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: an UNGAP review,” European Journal of Pharmaceutical Sciences, vol. 162, 2021. 4. [4] S. Adepu, Ramakrishna S., “Controlled drug delivery systems: current status and future directions,”Molecules, vol. 26, no. 19, pp. 5905, 2021. 5. [5] S. Hua, “Advances in oral drug delivery for regional targeting in the gastrointestinal tract - ınfluence of physiological, pathophysiological and pharmaceutical factors,“ Frontiers in Pharmacology, vol. 11, 2020.
|
|