Bioactivity of Ginger (Zingiber officinale Rosc), Citronella (Cymbopogonnardus (L.) and Cinnamon (Cinnamomum burmannii B) Against Decreased Blood Sugar Levels of Alloxan-induced (Rattus Novergicus)

Abstract

Purpose: To see the potency of mixed extracts of Ginger (Zingiber officinal Rosc.), Citronella (Cymbopogon nardus (L.) Randle, Cinnamon (Cinnamomum burmanii B.)  Against blood sugar levels in alloxan-induced Novergicus Rattus male rats.   Theoretical reference: Insulin resistance is necessary to maintain dysglycemia, where insulin levels are higher than usual. Insulin resistance often occurs in people who are overweight, commonly known as obesity. 2. Pancreatic B Cell Dysfunction, decreased pancreatic beta cell function, and continued increase in insulin resistance, causing chronic hyperglycemia and stage liver disease. 3. Environmental factors are individuals who consume excessive carbohydrates and sugars.   Method: Using Complete Randomized Design (RAL) consisting of 7 groups with 4 repetitions, namely K0 (Normal group), K- (Negative group), K+ (Positive group given meformin), K1, K2, K3 and K4 (mixed extracts of ginger, lemongrass, cinnamon 100, 200, 300 and 400mg/kg bw), The data obtained were analyzed using ANOVA with a sig < 0.05.   Results and conclusion: It showed that the administration of mixed extracts of Ginger (Zingiber officinal Rosc.), Citronella (Cymbopogon nardus (L.) Randle, Cinnamon (Cinnamomum burmanii B.) affected reducing blood glucose levels and improving pancreatic histology. A mixed extract dose of Ginger (Zingiber officinal Rosc.), Citronella (Cymbopogon nardus (L.) Randle, Cinnamon (Cinnamomum burmanii B.) 400 mg/kg bw was most effective in lowering blood glucose levels and improving alloxan-induced pancreatic histology.   Implications of the research: When you want to control blood sugar, you can use a mixture of Ginger (Zingiber officinale Rosc), Citronella (Cymbopogonnardus (L.), and Cinnamon (Cinnamomum burmannii B) extracts in balanced portions).   Originality/Value: Ginger (Zingiber officinale Rosc), Citronella (Cymbopogon Nardus (L.), and Cinnamon (Cinnamomum burmannii B) have potential as herbal medicine ingredients.