ASSOCIATION OF THE ADRB2 GENE POLYMORPHIC VARIANT C79G (rs1072714) WITH THE COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN OBESE AND NON-OBESE PATIENTS

Abstract

Introduction: Attention has been paid to studying the role of the sympathetic nervous system and polymorphism of the β2-adrenoceptor genes in the development of chronic obstructive pulmonary disease (COPD) in recent years, but the findings of the studies contradict each other.Objective:  To establish an association between the ADRB2 gene polymorphic variant C79G (rs1072714) in obese and non-obese COPD patients.Methods: The study involved 48 obese COPD patients and 52 nonobese COPD patients. The ADRB2 gene polymorphic variant C79G (rs1072714) was genotyped and assessed by the CAT test and the BODE index.Results: It has been established that in obese COPD patients the CAT test was significantly higher in the genotype GG (24.25 ± 4.25) compared to those with obesity and the genotype CC and CG (p <0.05). The BODE index was significantly (p <0.05) lower in obese COPD patients. A strong positive correlation between BMI and FEV1 (r = 0.742, p = 0.014) in nonobese COPD patients with GG genotype has been found.Conclusion:  According to the CAT test, the quality of life in obese COPD patients with GG genotype is worse. The BODE index in obese COPD patients with CC and CG genotypes was significantly lower than in those without obesity. A strong positive correlation between BMI and FEV1 in COPD patients without obesity with GG genotype has been established.