M1 Muscarinic Acetylcholine Receptor Agonism Alters Sleep without Affecting Memory Consolidation

Author:

Nissen Christoph12,Power Ann E.3,Nofzinger Eric A.2,Feige Bernd1,Voderholzer Ulrich1,Kloepfer Corinna1,Waldheim Bernhard1,Radosa Marc-Philipp1,Berger Mathias1,Riemann Dieter1

Affiliation:

1. 1Albert-Ludwigs-University Freiburg, Germany

2. 2University of Pittsburgh School of Medicine

3. 3University of California, Irvine

Abstract

Abstract Preclinical studies have implicated cholinergic neurotransmission, specifically M1 muscarinic acetylcholine receptor (mAChR) activation, in sleep-associated memory consolidation. In the present study, we investigated the effects of administering the direct M1 mAChR agonist RS-86 on pre-post sleep memory consolidation. Twenty healthy human participants were tested in a declarative word-list task and a procedural mirror-tracing task. RS-86 significantly reduced rapid eye movement (REM) sleep latency and slow wave sleep (SWS) duration in comparison with placebo. Presleep acquisition and postsleep recall rates were within the expected ranges. However, recall rates in both tasks were almost identical for the RS-86 and placebo conditions. These results indicate that selective M1 mAChR activation in healthy humans has no clinically relevant effect on pre-post sleep consolidation of declarative or procedural memories at a dose that reduces REM sleep latency and SWS duration.

Publisher

MIT Press - Journals

Subject

Cognitive Neuroscience

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