Dissociating Cerebellar Regions Involved in Formulating and Articulating Words and Sentences

Author:

Parker Jones Oiwi123ORCID,Geva Sharon14ORCID,Prejawa Susan1ORCID,Hope Thomas M. H.1ORCID,Oberhuber Marion1ORCID,Seghier Mohamed L.5ORCID,Green David W.6ORCID,Price Cathy J.1ORCID

Affiliation:

1. Wellcome Centre for Human Neuroimaging, University College London, London, UK

2. Department of Engineering Science, University of Oxford, Oxford, UK

3. Jesus College, University of Oxford, Oxford, UK

4. Centre for Mind and Behaviour, Anglia Ruskin University, Cambridge, UK

5. Healthcare Engineering Innovation Center (HEIC), Biomedical Engineering Department, Khalifa University of Science and Technology, Abu Dhabi, UAE

6. Experimental Psychology, University College London, London, UK

Abstract

Abstract We investigated which parts of the cerebellum are involved in formulating and articulating sentences using (i) a sentence production task that involved describing simple events in pictures; (ii) an auditory sentence repetition task involving the same sentence articulation but not sentence formulation; and (iii) an auditory sentence-to-picture matching task that involved the same pictorial events and no overt articulation. Activation for each of these tasks was compared to the equivalent word processing tasks: noun production, verb production, auditory noun repetition, and auditory noun-to-picture matching. We associate activation in bilateral cerebellum lobule VIIb with sequencing words into sentences because it increased for sentence production compared to all other conditions and was also activated by word production compared to word matching. We associate a paravermal part of right cerebellar lobule VIIIb with overt motor execution of speech, because activation was higher during (i) production and repetition of sentences compared to the corresponding noun conditions and (ii) noun and verb production compared to all matching tasks, with no activation relative to fixation during any silent (nonspeaking) matching task. We associate activation within right cerebellar Crus II with covert articulatory activity because it activated for (i) all speech production more than matching tasks and (ii) sentences compared to nouns during silent (nonspeaking) matching as well as sentence production and sentence repetition. Our study serendipitously segregated, for the first time, three distinct functional roles for the cerebellum in generic speech production, and it demonstrated how sentence production enhanced the demands on these cerebellar regions.

Funder

Wellcome Trust

Medical Research Council

Publisher

MIT Press

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