Functional Connectivity under Anticipation of Shock: Correlates of Trait Anxious Affect versus Induced Anxiety

Author:

Bijsterbosch Janine12,Smith Stephen1,Bishop Sonia J.12

Affiliation:

1. 1University of Oxford

2. 2University of California, Berkeley

Abstract

Abstract Sustained anxiety about potential future negative events is an important feature of anxiety disorders. In this study, we used a novel anticipation of shock paradigm to investigate individual differences in functional connectivity during prolonged threat of shock. We examined the correlates of between-participant differences in trait anxious affect and induced anxiety, where the latter reflects changes in self-reported anxiety resulting from the shock manipulation. Dissociable effects of trait anxious affect and induced anxiety were observed. Participants with high scores on a latent dimension of anxious affect showed less increase in ventromedial pFC–amygdala connectivity between periods of safety and shock anticipation. Meanwhile, lower levels of induced anxiety were linked to greater augmentation of dorsolateral pFC–anterior insula connectivity during shock anticipation. These findings suggest that ventromedial pFC–amygdala and dorsolateral pFC–insula networks might both contribute to regulation of sustained fear responses, with their recruitment varying independently across participants. The former might reflect an evolutionarily old mechanism for reducing fear or anxiety, whereas the latter might reflect a complementary mechanism by which cognitive control can be implemented to diminish fear responses generated due to anticipation of aversive stimuli or events. These two circuits might provide complementary, alternate targets for exploration in future pharmacological and cognitive intervention studies.

Publisher

MIT Press - Journals

Subject

Cognitive Neuroscience

Reference71 articles.

1. Andersson, J. L. R., Jenkinson, M., & Smith, S. M. (2007a). Non-linear optimisation. FMRIB Technical Report (Vol. 7). http://www.fmrib.ox.ac.uk/analysis/techrep/tr07ja1.pdf.

2. Andersson, J. L. R., Jenkinson, M., & Smith, S. M. (2007b). Non-linear registration, aka spatial normalisation. FMRIB Technical Report (Vol. 7). http://www.fmrib.ox.ac.uk/analysis/techrep/tr07ja2/tr07ja2.pdf.

3. An inventory for measuring depression;Beck;Archives of General Psychiatry,1961

4. Probabilistic independent component analysis for functional magnetic resonance imaging;Beckmann;IEEE Transactions on Medical Imaging,2004

5. The State-Trait Anxiety Inventory, Trait version: Structure and content re-examined;Bieling;Behaviour Research and Therapy,1998

Cited by 20 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3