H.M. Revisited: Relations between Language Comprehension, Memory, and the Hippocampal System

Abstract

Three studies tested the claim that H.M. exhibits a fipure memory deficitfl that has left his ability to comprehend language unimpaired relative to memory-normal controls. In Study 1, H.M. and memory-normal controls of comparable intelligence, education, and age indicated whether sentences were ambiguous or unambiguous, and H.M. detected ambiguities significantly less often than controls. In Study 2, participants identified the two meanings of visually presented sentences that they knew were ambiguous, and relative to controls, H.M. rarely discovered the ambiguities without help and had difficulty understanding the first meanings, experimenter requests, and his own output. Study 3 replicated these results and showed that they were not due to brain damage per se or to cohort effects: Unlike H.M., a patient with bilateral frontal lobe damage detected the ambiguities as readily as young and same-cohort older controls. These results bear on two general classes of theories in use within a wide range of neurosciences and cognitive sciences: The data favor fidistributed-memory theoriesfl that ascribe H.M.'s deficit to semantic-level binding processes that are inherent to both language comprehension and memory, over fistages-of-processing theories, fl where H.M.'s defective storage processes have no effect on language comprehension.