Dimensions of early life adversity and their associations with functional brain organisation

Abstract

Abstract Early life adversity is associated with differences in brain function and an elevated risk for poor mental health. Using data from children aged 10 (N = 5,798) from the Adolescent Brain Cognitive Development (ABCD) cohort, we investigated how adversity relates to functional brain organisation using a network neuroscience approach. We derived four data-driven categories of adversity by fitting a mixed graphical model: household/community instability, physical/sexual abuse, parental neglect, and financial difficulties. Analyses revealed that multiple forms of adversity were associated with reduced clustering and increased assortativity across the entire brain and that these local measures of organisation captured greater adversity-related variance than mesoscale measures like modularity. The most pronounced effects were in the somatosensory and subcortical networks. Financial difficulties showed the strongest and most widespread associations with brain organisation, with evidence of a mediating effect of assortativity on the association between financial difficulties and internalising symptoms. Adding race as a covariate attenuated most brain-adversity relationships, suggesting that experiences of adversity are strongly related to race/ethnicity in the ABCD sample. These results demonstrate that different forms of adversity are associated with both shared and unique variations in functional brain organisation, highlighting its potential significance for explaining individual differences in mental health outcomes following early life adversity.