Contribution of the ABC Transporters Bcrp1 and Mdr1a/1b to the Side Population Phenotype in Mammary Gland and Bone Marrow of Mice-Reference-Cited by-同舟云学术

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Contribution of the ABC Transporters Bcrp1 and Mdr1a/1b to the Side Population Phenotype in Mammary Gland and Bone Marrow of Mice

Published:2005-09 Issue:8 Volume:23 Page:1059-1065
ISSN:1066-5099
Container-title:STEM CELLS
language:en
Short-container-title:STEM CELLS

Author:

Jonker Johan W.¹,Freeman Jamie²,Bolscher Ellen¹,Musters Sandra¹,Alvi Azra J.³,Titley Ian³,Schinkel Alfred H.¹,Dale Trevor C.²³

Affiliation:

1. The Netherlands Cancer Institute, Division of Experimental Therapy, Plesmanlaan, Amsterdam, The Netherlands

2. School of Biosciences, Cardiff University, Cardiff, United Kingdom

3. Institute of Cancer Research, Section of Cell and Molecular Biology, London, United Kingdom

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1634/stemcells.2005-0150

Reference34 articles.

1. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

2. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

3. Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo

4. Hematopoietic cells from mice that are deficient in both Bcrp1/Abcg2 and Mdr1a/1b develop normally but are sensitized to mitoxantrone

5. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors

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