A Scaleable and Defined System for Generating Neural Stem Cells from Human Embryonic Stem Cells-Reference-Cited by-同舟云学术

A Scaleable and Defined System for Generating Neural Stem Cells from Human Embryonic Stem Cells

Published:2006-11-09 Issue:3 Volume:25 Page:731-737
ISSN:1066-5099
Container-title:Stem Cells
language:en
Short-container-title:

Author:

Joannides Alexis J.¹,Fiore-Hériché Christelle¹,Battersby Alysia A.²,Athauda-Arachchi Pandula¹,Bouhon Isabelle A.¹,Williams Lydia²,Westmore Kristine¹,Kemp Paul J.²,Compston Alastair¹,Allen Nicholas D.²,Chandran Siddharthan¹

Affiliation:

1. Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, Cambridge, United Kingdom

2. School of Biosciences, Cardiff University, Cardiff, United Kingdom

Abstract

Abstract The ability to differentiate human ESCs (hESCs) to defined lineages in a totally controlled manner is fundamental to developing cell-based therapies and studying human developmental mechanisms. We report a novel, scaleable, and widely applicable system for deriving and propagating neural stem cells from hESCs without the use of animal products, proprietary formulations, or genetic manipulation. This system provides a definitive platform for studying human neural development and has potential therapeutic implications.

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1634/stemcells.2006-0562

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