Interethnic Differences in Genetic Polymorphisms of CYP2D6 in the U.S. Population: Clinical Implications-Reference-Cited by-同舟云学术

Interethnic Differences in Genetic Polymorphisms of CYP2D6 in the U.S. Population: Clinical Implications

Published:2006-02-01 Issue:2 Volume:11 Page:126-135
ISSN:1083-7159
Container-title:The Oncologist
language:en
Short-container-title:

Author:

Bernard Stephen¹,Neville Kathleen A.²,Nguyen Anne T.²,Flockhart David A.²

Affiliation:

1. a Division of Hematology and Medical Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

2. b Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA

Abstract

Learning Objectives After completing this course, the reader will be able to: List the four different genotypes for CYP2D6 polymorphism.Understand the potential effects of CYP2D6 polymorphism on the efficacy and safety for drugs metabolized via this enzyme.List the ethnic groups that are most frequently affected by genetic variation of the CYP2D6 enzyme. CME Access and take the CME test online and receive 1 AMA PRA category 1 credit at CME.TheOncologist.com

Funder

Pharmacogenetics Research Network

Clinical Pharmacology Training

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1634/theoncologist.11-2-126

Reference76 articles.

1. Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment;Ingelman-Sundberg;Trends Pharmacol Sci,1999

2. Moving towards individualized medicine with pharmacogenomics;Evans;Nature,2004