What to Do with an Abnormal PSA Test

Abstract

Abstract Learning Objectives After completing this course, the reader will be able to: Take advantage of the use of total PSA thresholds for predicting prostate cancer risk and determining the need for prostate biopsy.Distinguish prostate cancer from benign conditions based on the relative proportions of complexed and free forms.Use PSA density as a means to correct for the effect of prostate volume on the PSA level.Explain the evolving role of PSA kinetics in the prediction of aggressive prostate cancer.Perform the calculations for PSA velocity and PSA doubling time. CME Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com For more than a decade, prostate-specific antigen (PSA) has been used for prostate cancer screening. Over the years, this screening has been continually refined, including investigation into the use of lower total PSA thresholds, PSA isoforms, and PSA kinetics. This review describes the evolution of prostate cancer screening and provides clinical insights into the informed use of PSA and its adjunctive measurements.