Recent Advances in Combined Modality Therapy

Author:

Mierzwa Michelle L.1,Nyati Mukesh K.1,Morgan Meredith A.1,Lawrence Theodore S.1

Affiliation:

1. Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA

Abstract

Abstract Combined modality therapy emerged from preclinical data showing that carefully chosen drugs could enhance the sensitivity of tumor cells to radiation while having nonoverlapping toxicities. Recent advances in molecular biology involving the identification of cellular receptors, enzymes, and pathways involved in tumor growth and immortality have resulted in the development of biologically targeted drugs. This review highlights the recent clinical data in support of newer generation cytotoxic chemotherapies and systemic targeted agents in combination with radiation therapy.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

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