Oligodendrogliomas: Molecular Biology and Treatment

Author:

Bromberg Jacolien E. C.1,van den Bent Martin J.1

Affiliation:

1. Neuro-Oncology Unit, Daniel den Hoed Cancer Center/Erasmus University Medical Center, Rotterdam, The Netherlands

Abstract

Learning Objectives Evaluate the current challenges in the histological diagnosis of oligodendroglial tumors and apply best practices to optimize patient outcomes. Analyze the molecular alterations in different subsets of tumors with oligodendroglial morphology. Formulate treatment options for your patients with newly diagnosed and recurrent oligodendroglial tumors. This article is available for continuing medical education credit at CME.TheOncologist.com.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Reference65 articles.

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2. Response rate and prognostic factors of recurrent oligodendroglioma treated with procarbazine, CCNU, and vincristine chemotherapy;Dutch Neuro-oncology Group;Neurology,1998

3. Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p;Reifenberger;Am J Pathol,1994

4. Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype;Smith;Oncogene,1999

5. Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytoma, and mixed oligoastrocytomas;Smith;J Clin Oncol,2000

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