How Do the Accrual Pattern and Follow-Up Duration Affect the Hazard Ratio Estimate When the Proportional Hazards Assumption Is Violated?-Reference-Cited by-同舟云学术

How Do the Accrual Pattern and Follow-Up Duration Affect the Hazard Ratio Estimate When the Proportional Hazards Assumption Is Violated?

Published:2018-09-10 Issue:7 Volume:24 Page:867-871
ISSN:1083-7159
Container-title:The Oncologist
language:en
Short-container-title:

Author:

Horiguchi Miki¹,Hassett Michael J.²,Uno Hajime²³

Affiliation:

1. Department of Clinical Medicine (Biostatistics), Kitasato University Graduate School of Pharmaceutical Sciences, Tokyo, Japan

2. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

3. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Abstract

In randomized clinical trials, the magnitude of the treatment effect is often reported using the hazard ratio (HR) even when the proportional hazards (PH) assumption is not met. Conducting numerical studies, this commentary illustrates how/why the HR estimate via the standard Cox's procedure is difficult to interpret even as an “average” treatment effect for non-PH cases.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1634/theoncologist.2018-0141

Reference19 articles.

1. Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis;Uno;J Clin Oncol,2014

2. Alternatives to hazard ratios for comparing the efficacy or safety of therapies in noninferiority studies;Uno;Ann Intern Med,2015

3. Restricted mean survival time: An obligatory end point for time-to-event analysis in cancer trials?;A'Hern;J Clin Oncol,2016

4. Describing differences in survival curves;Chappell;JAMA Oncol,2016

5. The net chance of a longer survival as a patient-oriented measure of treatment benefit in randomized clinical trials;Péron;JAMA Oncol,2016

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