Trastuzumab-Related Cardiotoxicity in Early Breast Cancer: A Cohort Study

Author:

Bonifazi Martina1,Franchi Matteo1,Rossi Marta12,Moja Lorenzo34,Zambelli Alberto5,Zambon Antonella6,Corrao Giovanni6,La Vecchia Carlo12,Zocchetti Carlo7,Negri Eva1

Affiliation:

1. Department of Epidemiology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCSS), Milan, Italy;

2. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy;

3. Department of Biomedical Sciences for Public Health, University of Milan, Milan, Italy;

4. Unit of Clinical Epidemiology, Galeazzi Orthopedic Institute, IRCCS, Milan, Italy;

5. Medical Oncology Unit, S. Maugeri Foundation, IRCCS, Pavia, Italy;

6. Unit of Biostatistics and Epidemiology, Department of Statistics, University of Milano-Bicocca, Milan, Italy;

7. Operative Unit of Territorial Health Service, Health Directorate, Regione Lombardia, Milan, Italy

Abstract

Learning Objectives Evaluate the frequency of trastuzumab-related serious cardiac events in clinical practice. Assess the cumulative incidence of cardiac disorders at 1, 2, and 3 years after first administration, irrespective of drug discontinuation. Identify predictors for the onset of cardiotoxicity.

Funder

Programma Straordinario Oncologia—Ministero della Salute

Fondazione Umberto Veronesi

Italian Association for Cancer Research

Italian Foundation for Cancer Research

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

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