Active Smoking May Negatively Affect Response Rate, Progression-Free Survival, and Overall Survival of Patients With Metastatic Renal Cell Carcinoma Treated With Sunitinib

Author:

Keizman Daniel1,Gottfried Maya1,Ish-Shalom Maya1,Maimon Natalie1,Peer Avivit2,Neumann Avivit2,Hammers Hans3,Eisenberger Mario A.3,Sinibaldi Victoria3,Pili Roberto4,Hayat Henry5,Kovel Svetlana6,Sella Avishay6,Boursi Ben7,Weitzen Rony7,Mermershtain Wilmosh8,Rouvinov Keren8,Berger Raanan7,Carducci Michael A.3

Affiliation:

1. Genitourinary Oncology Service, Institute of Oncology, Meir Medical Center and the Sackler School of Medicine, Tel Aviv University, Kfar-Saba, Israel;

2. Department of Oncology, Rambam Medical Center, Haifa, Israel;

3. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA;

4. Roswell Park Cancer Institute, Buffalo, New York, USA;

5. Department of Oncology, Wolfson Medical Center, Holon, Israel;

6. Department of Oncology, Asaf Harofe Medical Center, Zerifin, Israel;

7. Department of Oncology, Sheba Medical Center, Tel Hashomer, Israel;

8. Department of Oncology, Soroka University Medical Center, Beer-sheva, Israel

Abstract

Learning Objectives Describe the association between risk factors for renal cell carcinoma and the outcome of sunitinib treatment for metastatic disease. Explain the impact of active smoking on the outcome of sunitinib-treated metastatic renal cell carcinoma. Discuss obesity, hypertension, and diabetes in relation to the outcome of sunitinib-treated metastatic renal cell carcinoma.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

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