Harnessing the Energy: Development of Radioimmunotherapy for Patients with Non-Hodgkin’s Lymphoma

Author:

Gregory Stephanie A.1,Hohloch Karin2,Gisselbrecht Christian3,Tobinai Kensei4,Dreyling Martin5

Affiliation:

1. Rush University Medical Center, Chicago, Illinois, USA

2. Universitätsmedizin Göttingen, Göttingen, Germany

3. Hôpital Saint-Louis, Paris, France

4. National Cancer Center Hospital, Tokyo, Japan

5. Klinikum der Universität München, Munich, Germany

Abstract

Abstract Radioimmunotherapy (RIT) combines the use of targeted monoclonal antibodies with radionuclides for the treatment of non-Hodgkin’s lymphoma (NHL), taking advantage of its inherent radiosensitivity. A number of trials have shown significantly higher response rates and longer progression-free survival times in patients treated with the CD20-targeted radioimmunoconjugate yttrium-90-ibritumomab tiuxetan compared with the standard of care. Furthermore, these benefits have also been shown in heavily pretreated patients who relapsed or were resistant to rituximab. Currently, a number of different treatment regimens and strategies are available for the treatment of NHL patients. Therefore, in an attempt to minimize toxicity, maximize efficacy, and improve survival, it is crucial to appropriately select patients who are good candidates for individual treatment approaches. A strategy for patient selection has been developed, including the use of existing patient assessment tools, such as the Follicular Lymphoma International Prognostic Index, to determine the optimal regimen for patients with follicular lymphoma according to their disease characteristics and physical condition. Patients who are fit make ideal candidates for potentially curative regimens, which include induction chemotherapy with or without immunotherapy followed by RIT consolidation and, potentially, maintenance therapy. Patients who are considered “compromised” would also benefit from induction treatment and RIT consolidation, with a view to reducing the lymphoma burden and decreasing the risk for disease progression. “Frail” patients would be better suited to supportive therapy to control symptoms. This paper explores factors that should be considered when assessing whether a patient is a good candidate for treatment with RIT, and aids physicians in the selection of the most appropriate therapy for each patient group.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Cited by 15 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Tumor long-axis diameter and SUVmax predict long-term responders in 90Y-ibritumomab tiuxetan monotherapy;International Journal of Hematology;2018-09-10

2. Positron Emission Tomography/Computed Tomography before Treatment as a Predictor of 90Y-Ibritumomab Tiuxetan Response;The Kitakanto Medical Journal;2018-08-01

3. Radioimmunotherapy in the Transplant Setting;Clinical Applications of Nuclear Medicine Targeted Therapy;2018

4. Radiotherapeutic Management of Lymphomas;Neoplastic Diseases of the Blood;2017-09-23

5. Radioimmunotherapy in Lymphomas;Cancer Consult: Expertise for Clinical Practice;2014-06-20

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