Metformin Is Associated With Survival Benefit in Cancer Patients With Concurrent Type 2 Diabetes: A Systematic Review and Meta-Analysis

Author:

Yin Ming1,Zhou Jie2,Gorak Edward J.3,Quddus Fahd3

Affiliation:

1. Department of Internal Medicine, Danville, Pennsylvania, USA

2. Department of Radiology, Geisinger Medical Center, Danville, Pennsylvania, USA

3. Department of Hematology and Oncology, Geisinger Medical Center, Danville, Pennsylvania, USA

Abstract

Learning Objectives Describe the influences of different types of glucose-lowering medications on therapeutic outcomes of cancer patients who received standard anticancer treatment. Compare the survival associated with metformin treatment with survival in treatment with other glucose-lowering medications.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Reference54 articles.

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2. Diabetes and cancer: A consensus report;Giovannucci;Diabetes Care,2010

3. Metformin inhibits hepatic gluconeogenesis in mice independently of the lkb1/ampk pathway via a decrease in hepatic energy state;Foretz;J Clin Invest,2010

4. Metformin inhibits hepatic gluconeogenesis through amp-activated protein kinase-dependent regulation of the orphan nuclear receptor shp;Kim;Diabetes,2008

5. Metformin and pioglitazone: Effectively treating insulin resistance;Staels;Curr Med Res Opin,2006

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