Management of Cancer in the Older Age Person: An Approach to Complex Medical Decisions

Author:

Vallet-Regí María12,Manzano Miguel12,Rodriguez-Mañas Leocadio34,Checa López Marta5,Aapro Matti6,Balducci Lodovico7,

Affiliation:

1. Departamento de Química Inorgánica y Bioinorgánica Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, Madrid, Spain

2. Networking Research Center on Bioengineering Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain

3. Geriatrics Service, Madrid, Spain

4. Spanish Collaborative Research Network on Aging and Frailty (RETICEF)

5. Fundación para la Investigación Biomédica, Hospital Universitario de Getafe, Madrid, Spain

6. Breast Center, IMO Clinique de Genolier, Genolier, Switzerland

7. University of South Florida, College of Medicine H. Lee Moffitt Cancer Center & Research Institute, Senior Adult Oncology Program, Tampa, Florida, USA

Abstract

Abstract The management of cancer in older aged people is becoming a common problem due to the aging of the population. There are many variables determining the complex situation that are interconnected. Some of them can be assessed, such as risk of mortality and risk of treatment complications, but many others are still unknown, such as the course of disease, the host-related factors that influence cancer aggressiveness, and the phenotype heralding risk of permanent treatment-related damage. This article presents a dynamic and personalized approach to older people with cancer based on our experience on aging, cancer, and their biological interactions. Also, novel treatments and management approaches to older individuals, based on their functional age and their social and emotional needs, are thoughtfully explored here.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

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