Cancer Clinical Trials—Do We Need a New Algorithm in the Age of Stratified Medicine?-Reference-Cited by-同舟云学术

Cancer Clinical Trials—Do We Need a New Algorithm in the Age of Stratified Medicine?

Published:2013-05-22 Issue:6 Volume:18 Page:651-652
ISSN:1083-7159
Container-title:The Oncologist
language:en
Short-container-title:

Author:

Doroshow James H.¹,Sleijfer Stefan²,Stupp Roger³⁴,Anderson Kenneth⁵

Affiliation:

1. Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, USA;

2. Erasmus University Medical Center, Cancer Institute and Cancer Genomics, Netherlands Centre, Rotterdam, The Netherlands;

3. Department of Clinical Neurosciences, University of Lausanne and Cancer Centre, University Hospital Zurich, Lausanne and Zurich, Switzerland;

4. EORTC, Brussels, Belgium;

5. Department of Medicine, Harvard Medical School and Kraft Family Blood Center, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Abstract

The explosion in genomic discovery science and its application in oncology in recent years is underpinning an unprecedented increase in our understanding of mechanisms underlying malignant processes. An increased understanding creates challenges pertinent to the area of cancer clinical trial development and application. Although the existing cancer clinical trial algorithm has served us well in the past, is it still fit for purpose in the 21st century?

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Link

https://pericles-gcp.literatumonline.com/doi/pdf/10.1634/theoncologist.2013-0190

Reference6 articles.

1. Publicly funded clinical trials and the future of cancer care;Schilsky;The Oncologist,2013

2. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing;Gerlinger;N Engl J Med,2012

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