Possibilities of Application of Ethylmethylhydroxypyri dine Succinate in the Treatment of Acute Poisoning: a Systematic Literature Review

Abstract

   In recent years, there has been a trend of increasing poisoning by various substances among the general population throughout the world. For the complex treatment of these patients, modern toxicology uses a combination of drug and non-drug methods that have universal mechanisms aimed at restoring body functions. Currently, antihypoxants and antioxidants are actively used in medical practice in all situations where there are oxygen deficiency and certain manifestations of the ischemic cascade in order to interrupt the mechanisms of hypoxia progression as early as possible. The widespread use of ethylmethylhydroxypyridine succinate (Mexidol®, NPK PHARMASOFT LLC, Russia) both in the form of monotherapy and in combination with various methods of non-pharmacological intervention (mesodiencephalic modulation, hyperbaric oxygenation, etc.) is becoming quite interesting for practical use in toxicological practice for the treatment and rehabilitation of conditions developing after acute poisoning by neurotropic substances (psychodysleptics, drugs, ethanol and its substitutes).